The pharmaceutical industry, especially the branch which deals with erectile dysfunctions, has witnessed a gradual evolution, marked by the introduction of sildenafil (Viagra) and tadalafil (Cialis) in the late 20th century. These drugs, while effective, were not without their limitations, paving the way for the development of Avanafil. Unlike its predecessors, Avanafil promises not just efficacy but a quicker onset of action and potentially fewer side effects.


Scientific Breakdown:


Avanafil, a phosphodiesterase type 5 (PDE5) inhibitor, exerts its effects by enhancing the effects of nitric oxide, a natural chemical in the body that relaxes penile muscles. This increased blood flow to the penis results in improved erectile function. The uniqueness of Avanafil lies in its rapid onset of action, taking effect as quickly as 15 minutes in some individuals. This swift response time not only sets it apart from its competitors but also addresses a key concern among users – spontaneity.


Here’s a step-by-step explanation of the science of Avanafil action:


Nitric Oxide Release:

    • Sexual stimulation triggers the release of nitric oxide (NO) from nerve endings and endothelial cells in the erectile tissue of the penis.

cGMP Production:

    • Nitric oxide activates the enzyme guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP) production within the smooth muscle cells of the penile arteries and corpus cavernosum.

Smooth Muscle Relaxation:

    • Elevated cGMP levels result in the relaxation of smooth muscle cells in the penile arteries and the corpus cavernosum. This relaxation allows increased blood flow into the penis.

Increased Blood Flow:

    • As the smooth muscle relaxes, the blood vessels dilate, and blood flow to the erectile tissue increases, resulting in an erection.

PDE5 Inhibition by Avanafil:

    • Avanafil acts by inhibiting phosphodiesterase type 5 (PDE5), an enzyme that breaks down cGMP. By inhibiting PDE5, Avanafil prolongs the effects of nitric oxide and cGMP, sustaining the relaxation of smooth muscle in the penile arteries and corpus cavernosum.

Enhanced Erectile Response:

    • By blocking the action of PDE5, Avanafil enhances the natural physiological process of achieving and maintaining an erection. This mechanism allows for improved erectile function and increased rigidity.

The Differences Between Avanafil (Stendra), Vardenafil (Levitra), Tadalafil (Cialis) And Sidenafil (Viagra)

Avanafil, Tadalafil, Sildenafil, and Vardenafil are all phosphodiesterase type 5 (PDE5) inhibitors used in the treatment of erectile dysfunction (ED). While they share a common mechanism of action, there are differences in their pharmacokinetics, onset of action, and duration of effect. The choice of which one works better often depends on individual factors, preferences, and the specific needs of the user. Here are some key differences:

Onset of Action:

    • Avanafil: Known for its rapid onset of action, typically within 15 to 30 minutes.
    • Tadalafil: Has a relatively slower onset compared to Avanafil, taking effect within 30 minutes to 2 hours.
    • Sildenafil: Usually takes effect within 30 minutes to 1 hour.
    • Vardenafil: Similar to Sildenafil, with an onset of action within 30 minutes to 1 hour.

Duration of Action:

    • Avanafil: Has a shorter duration of action compared to some other PDE5 inhibitors, typically lasting around 4 to 6 hours.
    • Tadalafil: Known for its extended duration, up to 36 hours, earning it the nickname “the weekend pill.”
    • Sildenafil: Typically lasts around 4 to 6 hours.
    • Vardenafil: Similar to Sildenafil, with a duration of action around 4 to 6 hours.


    • Avanafil: Exhibits selectivity for PDE5, particularly in the erectile tissue, potentially minimizing side effects on other body systems.
    • Tadalafil, Sildenafil, and Vardenafil: Also selectively inhibit PDE5, but their selectivity profiles may differ slightly.

Food Interaction:

    • Avanafil: Can be taken with or without food, but high-fat meals may delay its onset of action.
    • Tadalafil: Can be taken with or without food.
    • Sildenafil and Vardenafil: Should be taken on an empty stomach for optimal absorption.

Dosage Frequency:

    • Avanafil: Typically taken as needed, before sexual activity.
    • Tadalafil: Can be taken on a daily basis at a lower dose for continuous effectiveness or as needed.
    • Sildenafil and Vardenafil: Usually taken as needed before sexual activity.

Individual Response:

    • Response to these medications can vary among individuals. What works well for one person may not be as effective or may cause more side effects in another. Therefore, it’s important to consult with a healthcare professional to determine the most suitable option based on individual health and preferences.

Which One Works Better?

The effectiveness of Avanafil, Tadalafil, Sildenafil, or Vardenafil is subjective and varies from person to person. Factors such as individual health, the cause of erectile dysfunction, and lifestyle preferences play a role in determining which medication may be more suitable. It’s essential to consult with a healthcare provider to discuss personal health history and receive personalized recommendations.

Risks Associated With Avanafil Use

Avanafil, like other phosphodiesterase type 5 (PDE5) inhibitors used for the treatment of erectile dysfunction, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary among individuals. Here is a list of potential side effects associated with Avanafil:

Common Side Effects:

    • Headache: A common side effect reported by individuals taking Avanafil.
    • Flushing: Facial flushing, characterized by warmth and redness in the face and neck.
    • Nasal Congestion: Stuffy or runny nose.
    • Back Pain: Some users may experience back pain.
    • Dizziness: Feeling lightheaded, especially when standing up quickly.

Gastrointestinal Side Effects:

    • Indigestion: Digestive system-related side effects, such as upset stomach or indigestion.

Visual Disturbances:

    • Mild and transient changes in vision, such as blurred vision or changes in color perception.

Muscle Aches:

    • Muscular discomfort or aching, often in the back or limbs.

Priapism (Rare):

    • Priapism is a rare but serious side effect characterized by a prolonged and painful erection. Immediate medical attention is required.

It’s important to seek medical attention if any side effects persist, worsen, or if there are signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness, difficulty breathing).

Individuals with pre-existing medical conditions, especially those with cardiovascular issues, should inform their healthcare provider before starting Avanafil or any other PDE5 inhibitor. Serious interactions can occur with certain medications, and healthcare professionals will consider these factors when prescribing the medication.

This list is not exhaustive, and individuals should carefully read the medication’s accompanying information, discuss any concerns with their healthcare provider, and report any unusual or severe side effects promptly. Always follow the prescribed dosage and guidelines provided by the healthcare professional.

Avanafil’s Future and Challenges

Predicting the future evolution of a pharmaceutical product like Avanafil involves various uncertainties, including regulatory developments, advancements in medical research, changes in market dynamics, and shifts in healthcare practices. However, we can make some general projections based on current trends and potential areas of development. Please note that these forecasts are speculative and subject to change:

Market Expansion:

  • Avanafil may see increased global market penetration as awareness grows and regulatory approvals are obtained in additional countries.

Research and Development:

  • Ongoing research may explore new applications for Avanafil, potentially extending its use beyond erectile dysfunction. Clinical trials may focus on specific patient populations or investigate combination therapies.

Generic Versions:

  • Over the next decade, generic versions of Avanafil may become available, leading to increased affordability and accessibility for patients.

Treatment Guidelines:

  • Depending on further research outcomes, Avanafil may find its place in updated treatment guidelines for erectile dysfunction, potentially being recommended as a first-line or alternative therapy.

Combination Therapies:

  • Research may explore combination therapies involving Avanafil and other agents to enhance treatment outcomes or address specific aspects of sexual health.

Telemedicine Integration:

  • With the growing importance of telemedicine, Avanafil prescriptions may be facilitated through online platforms, making it more accessible to individuals seeking remote healthcare.

Personalized Medicine:

  • Advancements in genetic and biomarker research may contribute to the development of personalized approaches to ED treatment, potentially impacting the use of Avanafil based on individual profiles.

Focus on Side Effect Profiles:

  • Ongoing research may aim to further refine the side effect profile of Avanafil or develop formulations with even fewer side effects, improving overall patient satisfaction.

Regulatory Updates:

  • Regulatory agencies may update guidelines or requirements for ED medications, influencing how Avanafil is prescribed and used.

Patient Education and Awareness:

  • Increased efforts in patient education and awareness campaigns may contribute to a better understanding of Avanafil’s benefits, potentially leading to higher patient adherence and satisfaction.

Lifestyle Factors:

  • Changes in lifestyle factors, such as increasing sedentary behavior or rising stress levels, may contribute to a continued demand for effective ED treatments, including Avanafil.

Continued Competition:

  • Avanafil may face increased competition from new entrants in the ED treatment market, potentially prompting ongoing improvements, pricing adjustments, or strategic marketing efforts.